Enhanced penetration of lipid functionalized nanoparticles in 3D cell cultures

نویسندگان

  • Christopher Gene England
  • Andre Gobin
چکیده

S:Christopher G. England, Justin Huang, Hermann Frieboes, and LaceyMcNally. “Active targeting of EMPRINN receptors using S100A9functionalized liposomes in melanoma and pancreatic cancers.” WorldMolecular Imaging Conference, 2013.Lacey McNally, Justin Huang, Christopher G. England, Hermann B. Frieboes.“Detection of Hypoxia in Orthotopic Pancreatic Tumors In Vivo UsingMultispectral Optoacoustic Tomography.” World Molecular ImagingConference, 2013. Christopher G. England, Guandong Zhang, Xinghua Sun, Andre Gobin, andHermann B. Frieboes. “Nanoparticle Penetration into Solid Tumors.” JamesGraham Brown Cancer Center Conference, 2012. Christopher G. England, Guandong Zhang, Xinghua Sun, Andre Gobin, andHermann B. Frieboes “Optimization of Nanoparticle Diffusion into SolidTumors.” Research Louisville, 2012.COURSEWORK: Graduate Coursework in Biochemistry, Principles of Drug Action,Pharmacology and Toxicology, Research Methods, Cell Biology, Biostatistics,Grant Writing, Ethical Research Conduct, and Molecular Biology. SKILLS:Cell Culture Work (monolayer and 3D cell cultures, along with co-cultures),Animal Work (including imaging using multispectral optoacustic tomography,bioluminescence, and x-ray), Nanoparticle Synthesis and Characterization(Organic and Inorganic Synthesis of Nanoparticles along with numerous

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Water-based Double Layer Functionalized Iron Oxide Nanoparticles for Enhanced Gene Delivery Applications

Iron oxide nanoparticles (magnetite (Fe3O4), hematite (Fe2O3)) have been received increasing attention in drug and gene delivery. In this work, water-base double layer functionalized iron oxide nanoparticles (DL-IONPs) were designed and prepared of a biodegradable, biocompatible carrier by co-precipitation method with high DNA loading capacity due to self-assembly of a second organic layer. The...

متن کامل

Interplay of electrostatics and lipid packing determines the binding of charged polymer coated nanoparticles to model membranes.

Understanding of nanoparticle-membrane interactions is useful for various applications of nanoparticles like drug delivery and imaging. Here we report on the studies of interaction between hydrophilic charged polymer coated semiconductor quantum dot nanoparticles with model lipid membranes. Atomic force microscopy and X-ray reflectivity measurements suggest that cationic nanoparticles bind and ...

متن کامل

The Effect of Rosmarinic Acid in Neural Differentiation of Wartons Jelly-derived Mesenchymal Stem Cells in Two Dimensional and Three Dimensional Cultures using Chitosan-based Hydrogel

Numerous studies have shown the positive effects of rosmarinic acid on the nervous system. Rosmarinic acid as a herbal compound with anti-inflammatory effects can prevent the destructive effect of inflammation on the nervous system. Furthermore, various studies have emphasized the advantages of three dimensional (3D) culture over the two dimensional (2D) culture of cells. In this study, thermos...

متن کامل

Functionalized Nanostructures with Application in Regenerative Medicine

In the last decade, both regenerative medicine and nanotechnology have been broadly developed leading important advances in biomedical research as well as in clinical practice. The manipulation on the molecular level and the use of several functionalized nanoscaled materials has application in various fields of regenerative medicine including tissue engineering, cell therapy, diagnosis and drug...

متن کامل

Enhanced penetration into 3D cell culture using two and three layered gold nanoparticles

Nano-scale particles sized 10-400 nm administered systemically preferentially extravasate from tumor vasculature due to the enhanced permeability and retention effect. Therapeutic success remains elusive, however, because of inhomogeneous particle distribution within tumor tissue. Insufficient tumor vascularization limits particle transport and also results in avascular hypoxic regions with non...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2017